Hairpin-shaped DNA interacts with microRNA in cancer cells, activating an immune response. University of Tokyo researchers have made a breakthrough in the fight against cancer with the use of artificial DNA. In laboratory tests, the method effectively targeted and destroyed human cervical and breas
Scientists in Japan have made a breakthrough in the fight against cancer using artificial DNA. Lab tests successfully targeted and destroyed human cervical and breast cancer cells, as well as mouse malignant melanoma cells.researchers have made a breakthrough in the fight against cancer with the use of artificial. In laboratory tests, the method effectively targeted and destroyed human cervical and breast cancer cells, as well as malignant melanoma cells from mice.
Cancer is a sadly familiar global health concern and current methods of treatment have their limitations. However, drugs based on nucleic acids — namely DNA and, the vital information-carrying molecules — can control the biological functions of cells and are expected to transform the future of medicine and provide a significant boost towards efforts to overcome cancer and other hard-to-treat illnesses, caused by viruses and genetic diseases.
Cancer cells can overexpress, or make too many copies of, certain DNA or RNA molecules, causing them to not function normally. The team created artificial oncolytic hairpin DNA pairs called oHPs. These oHPs were triggered to form longer DNA strands when they encountered a short RNA called miR-21, which is overexpressed in some cancers.
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