It's well established that regular exercise benefits our bodies, not least in protecting against obesity, but scientists are continuing to look more closely at why this happens on a molecular level.
benefits our bodies, not least in protecting against obesity, but scientists are continuing to look more closely at why this happens on a molecular level.In a new study, scientists put mice on intense treadmill workouts and analyzed how the chemicals in the cells of the animals then began to change over time. They found the appearance of a metabolite called Lac-Phe , synthesized from lactate and phenylalanine.
The study authors think they've found an important biological pathway opened up by exercise, which then has an impact on the rest of the body – specifically in the level of appetite and the amount of food taken in. Over a period of 10 days, the Lac-Phe doses led to a drop in food intake, a resulting drop in body weight, and improved glucose tolerance in the mice. Those are positive results when thinking about ways to combat obesity and obesity-related disease.There were some caveats, though. The differences in appetite suppression caused by Lac-Phe were only noticeable after exercise and in mice on a high-fat diet. The same effects weren't seen in more sedentary mice fed normally.
By shedding more light on the molecular responses to physical activity, the findings of the study will help in a number of areas of research, including treatments.
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