The research could be used to develop more targeted kidney cancer drugs. Researchers from Sweden's Karolinska Institutet have discovered a connection between reduced mitochondrial content in cells and resistance to treatment for a lethal type of kidney cancer. The cancer cells reacted to the treatm
The research could be used to develop more targeted kidney cancer drugs.have discovered a connection between reduced mitochondrial content in cells and resistance to treatment for a lethal type of kidney cancer. The cancer cells reacted to the treatment when the researchers used an inhibitor to boost the mitochondrial content. Their research, which was published inIn order to create energy for the cell, mitochondria need oxygen.
Healthy cells are prevented from becoming cancerous by a gene called von Hippel-Lindau . The 2019 Nobel Prize in Physiology or Medicine was awarded to the discovery that VHL was part of the cell’s oxygen detection system. Normally, VHL breaks down another protein called HIF. Consequently, when VHL is mutated, HIF accumulates and causes a disease called VHL syndrome in which the cells react as if they lack oxygen despite oxygen being present.
To increase the amount of mitochondrial content in VHL-related kidney cancer cells, the researchers treated these tumors with an inhibitor of a mitochondrial protease called “LONP1”. The cells then became susceptible to the cancer drug sorafenib, which they had previously resisted. In mouse studies, this combination treatment led to reduced tumor growth.
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