Virus-like particles offer a new way to investigate genetic variation in SARSCoV2. Learn more in a new SciencePerspective:
introduced a key innovation. They first identified the SARS-CoV-2 packaging signal, a genetic marker used to identify full-length genomes for packaging into the virion . This packaging signal was incorporated into the 3’ untranslated region of a luciferase reporter plasmid, causing the resulting transcripts to be packaged within VLPs. Syedshow that VLPs deliver these luciferase reporters to target cells, allowing the resulting signal to be used as a proxy for SARS-CoV-2 infection.
In the broader context of studying SARS-CoV-2 genetic variation, VLPs represent a middle ground between two commonly used methodologies: infectious clones and pseudovirus vectors. SARS-CoV-2 infectious clones are the gold standard because they create recombinant virus, incorporating mutations anywhere in the genome . However, using SARS-CoV-2 infectious clones is technically challenging and creates live SARS-CoV-2 that requires BSL3 laboratories for study.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shiftNature research paper: Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Read more »
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shiftNature research paper: Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Read more »
A Total-Body Resistance Band Workout You Can Do AnywhereThe versatile tool will be your new favorite workout buddy.
Read more »
COVID-19 Omicron Variant's Symptoms Are Similar to the Common ColdEven though the world is prepared against the regular COVID-19, the virus has changed its ways as well with its new Omicron variant.
Read more »
UK PM Boris Johnson to assess latest omicron data before deciding on new Covid curbsScotland, Wales and Northern Ireland have already started new curbs to help stop the spread of the omicron variant.
Read more »
Rapid coronavirus tests: Are the at-home swabs picking up omicron? Experts say yesAs many people around the holidays shifted to using rapid coronavirus tests, infectious disease experts say they’re confident the at-home swabs are picking up the new omicron variant.
Read more »