People coinfected with SARS-CoV-2 and cytomegalovirus found to be at increased risk of developing cardiovasculardisease
Abbreviation: AS, aortic stenosis; CMV, cytomegalovirus; HDs, healthy donors; mCOVID-19, unvaccinated individuals with mild/asymptomatic SARS-CoV-2 infection; NA, not applicable; SARS-CoV-2, severe acute respiratory syndrome; coronavirus 2; SD, standard deviation; T1, time point 1 ; T2, time point 2 ; vmCOVID-19, vaccinated individuals with mild/asymptomatic SARS-CoV-2 infection.
Finally, patients with AS were recruited from June 2019 to January 2020. Their samples were collected at the time of their cardiovascular surgery, according to the following criteria: surgery indicated for valve replacement; no history or presence of cancer, endocrine disorders, renal failure, liver or autoimmune disease, or SARS-CoV-2 infection; and no current immunosuppressive treatment. None of the individuals in the cohort were immunoglobulin M seropositive for CMV.
The following plug-ins were used to perform uniform manifold approximation and projection reduction and FlowSOM clustering analysis among CD4
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