Copy number alteration in advanced prostate cancer associates with increased risk of metastases at diagnosis, according to a study published in GenomeMedicine.
]. Copy number calls and segmentation of 500-kb bins were performed using the CGHcall package. Segments are defined as merged neighbouring bins with similar copy number alteration. Copy number burden was defined as the number of genome segments classified as showing gain or loss compared to the median read count across the genome, divided by the total number of segments within the autosome.
STAMPEDE clinical trial outcome measures were defined in the STAMPEDE protocol and measured from time of randomisation to event. Patients without an event were censored at the most recent event-free clinical evaluation. The STAMPEDE clinical trial outcome measures of relevance to this ancillary biomarker study are as follows: primary outcome measure was overall survival .
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