Adoption of Mediterranean diet shows promise in easing symptoms for myeloproliferative neoplasm patients ChronicInflammation MPN Pathogenesis MediterraneanDiet DietIntervention InflammatoryBiomarkers Gut Microbiome Nutrition medrxivpreprint
By Dr. Priyom Bose, Ph.D.May 25 2023Reviewed by Benedette Cuffari, M.Sc. Myeloproliferative neoplasm represents a group of inflammatory diseases, including polycythemia vera , essential thrombocythemia , and primary myelofibrosis . MPNs are linked to hematologic malignancies and are characterized by clonal outgrowth of hematopoietic cells with an acquired mutation in JAK2.
Background Clinical manifestations of MPN include abnormal blood counts, thrombosis, and transformation to acute leukemia. One of the key characteristic features of MPN is increased plasma cytokines. Since many MPN patients do not meet the criteria for a cytoreductive agent, their symptoms are maintained without specific interventions. As a result, the quality of life of these patients is adversely affected due to the inability to limit disease progression.
About the study The primary aim of the current study was to determine the willingness of MPN patients to engage in dietary education to manage symptom burden. Participants were randomly assigned to either a standard U.S. Dietary Guidelines for Americans group or Mediterranean diet group. Both groups received separate but equal education through written dietary resources and registered dietician counseling.
In MPN, an important goal is to target symptoms, as symptoms can significantly affect the patient’s’ quality of life. In the USDA group, 31% of the cohort exhibited more than a 50% reduction in the MPN-Total Symptom Score at 15 weeks, whereas 53% of the Mediterranean diet group exhibited more than a 50% reduction in the MPN-TSS.
Future outlook Both diets investigated in the current study led to a reduction in MPN symptom burden. Thus, these findings demonstrate that a 10-week intervention is sufficient to detect a change in symptoms.
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