Aggressive luminal breast cancer: Are cis-spliced fusion proteins pathological?

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Aggressive luminal breast cancer: Are cis-spliced fusion proteins pathological?
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A new editorial paper titled 'Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer?' has been published in Oncotarget.

Three-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by Tom Misteli, Ph.D., and Karen Meaburn, Ph.D. at the NIH IRP.

A new editorial paper titled"Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer?" has been published inA vast majority of breast cancers are estrogen receptor-alpha positive , for which endocrine therapy is the common treatment. However, recurrence often occurs leading to tumor progression, metastasis and eventually patient death, and the underlying molecular mechanisms remain poorly understood.

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