Flanker Jac Morgan will captain the side as Williams partners Mason Grady in midfield
Basham failed a head injury assessment following a shoulder-led tackle to his head by England captain Owen Farrell at Twickenham last weekend.
Wales head coach Warren Gatland has made 13 changes from the side edged out 19-17 by England, with only full-back Liam Williams and flanker Dan Lydiate remaining in his starting XV. Gatland said: “Preparations have gone well. We are really pleased with the whole squad. We are trying to build some depth within the team, and there has been a great atmosphere.
Gatland’s opposite number Jacques Nienaber has selected a strong Springboks side, highlighted by the return from injury of their World Cup-winning captain Siya Kolisi.
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