Bet the under when it comes to point totals in the NFL these days.
That might as well be the league's new mantra with the pendumlum finally swinging back to defense, smacking the likes of Aaron Rodgers, Matthew Stafford, Tom Brady and Russell Wilson along the way.
People are also reading… Credit mostly the “shell” defenses popularized by former Broncos head coach Vic Fangio, who must be smirking as he watches from afar what he's wrought on the game that dumped him in favor of the latest young offensive-minded whiz kid — how's that working out, Denver? — but held on tightly to the old fogy's philosophies, especially in the red zone.
Brady was scowling on the sideline and staring at his first four-game losing streak in two decades Sunday when the Rams suddenly got conservative on both offense and defense, allowing the seven-time Super Bowl winner to show he has at least a little bit of magic left in that 45-year-old right arm. “So, when I decided to come back, I was all in,” Rodgers said."I don't make decisions and then hindsight 20/20, you know, have regrets about big decisions like that.”
Instead, there's been a lot of distress in Denver, although all that Broncos fans had to do last weekend was look around the league to realize they're not the only ones suffering through a quarterback quandary.
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Analysis: Bet the under; NFL pendulum has swung to defenseBet the under when it comes to point totals in the NFL these days.
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Frontiers | The epitranscriptome of Vero cells infected with SARS-CoV-2 assessed by direct RNA sequencing reveals m6A pattern changes and DRACH motif biases in viral and cellular RNAsThe epitranscriptomics of the SARS-CoV-2 infected cell reveals its response to viral replication. Among various types of RNA nucleotide modifications, the m6A is the most common and is involved in several crucial processes of RNA intracellular location, maturation, half-life and translatability. This epitranscriptome contains a mixture of viral RNAs and cellular transcripts. In a previous study we presented the analysis of the SARS-CoV-2 RNA m6A methylation based on direct RNA sequencing and characterized DRACH motif mutations in different viral lineages. Here we present the analysis of the m6A transcript methylation of Vero cells (derived from African Green Monkeys) and Calu-3 cells (human) upon infection by SARS-CoV-2 using direct RNA sequencing data. Analysis of these data by nonparametric statistics and two computational methods (m6anet and EpiNano) show that m6A levels are higher in RNAs of infected cells. Functional enrichment analysis reveals increased m6A methylation of transcripts involved in translation, peptide and amine metabolism. This analysis allowed the identification of differentially methylated transcripts and m6A unique sites in the infected cell transcripts. Results here presented indicate that the cell response to viral infection not only changes the levels of mRNAs, as previously shown, but also its epitranscriptional pattern. Also, transcriptome-wide analysis shows strong nucleotide biases in DRACH motifs of cellular transcripts, both in Vero and Calu-3 cells, which use the signature GGACU whereas in viral RNAs the signature is GAACU. We hypothesize that the differences of DRACH motif biases, might force the convergent evolution of the viral genome resulting in better adaptation to target sequence preferences of writer, reader and eraser enzymes. To our knowledge, this is the first report on m6A epitranscriptome of the SARS-CoV-2 infected Vero cells by direct RNA sequencing, which is the sensu stricto RNA-seq.
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Chris Rock Will Perform Netflix's First Ever Live Stand-Up ShowNetflix announced Thursday it is venturing into live streaming events with a comedy special from Chris Rock, following other streamers like Amazon Prime Video and AppleTV+ outside of pre-taped programming.
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