Patients with nonsevere COVID may avoid progression to hospitalization or death through treatment with nirmatrelvir-ritonavir or molnupiravir, according to a systematic review and meta-analysis.
Pitre and colleagues extracted data from randomized trials that compared antiviral therapies with placebo or standard care from the Epistemonikos COVID-19 L·OVE database through April 25, 2022. Forty-one trials involving 18,568 patients with nonsevere COVID-19 were included in the analysis. Participants' ages ranged between 36 and 65 years, and about half of participants were men.
Hospitalization risk was reduced with nirmatrelvir-ritonavir , compared with standard care or placebo. Molnupiravir probably reduced the risk , and remdesivir may have reduced the risk . "Adaptive platform trials and large observational studies offer the best opportunities to generate timely evidence on the effectiveness of COVID-19 therapeutics," write Corinne Hohl, MD, MHSc, associate professor of emergency medicine at University of British Columbia, Vancouver, and Andrew McRae, MD, PhD, assistant professor of emergency medicine at University of Calgary, Alberta, in an.
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