Evidence shows giving the initial Pfizer or Moderna COVID-19 vaccine shots eight weeks apart instead of three or four improves protection and lowers risk of rare but serious side effects.
Did we get the dose schedule of our COVID-19 vaccines a bit wrong? That’s a question experts at the Centers for Disease Control and Prevention are asking this month as health officials try to persuade more vaccine-eligible holdouts – about one in five Americans – to go for the shots.
Among key questions is whether a change in the dosing schedule will bolster vaccine confidence, or undermine it? Other countries that decided on longer gaps between doses were trying to make the most of limited vaccine supplies by getting the more limited protection from first shots into as many arms as possible before giving a second, which they also did not require to be from the same company.
The CDC’s review didn’t cover the Johnson & Johnson vaccine, given as a single shot with a booster after two months. And it’s not clear how any improved protection from spacing the Pfizer or Moderna shots farther apart would affect the need for a third booster shot.
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