Artificial sweeteners can raise blood glucose - gut microbiome appears to explain Artificial Sweeteners Microbiome bloodglucose Type2Diabetes Diabetes Type1Diabetes CellCellPress
By Dr. Liji Thomas, MDSep 5 2022Reviewed by Benedette Cuffari, M.Sc. Sugars are among the most commonly consumed flavoring agents, as their addictive sweetness enhances the taste of almost every other flavor. Sugar is found in a wide variety of foods, natural and otherwise. Furthermore, sugar provides instant energy and nourishes a wide range of commensal and symbiotic organisms in the human microbiome.
The current study summarizes available evidence on how the activity of the gut microbiome mediates this effect following exposure to these sweeteners. The current study presents novel insights on how exposure to NNS affects glycemic control in humans through its effects on the gut microbiome. Although previous studies have examined this aspect in rodents, limited studies are available on their impact on humans.
Related StoriesThis RCT included two arms, one of which involved adults who ingested one of these sweeteners daily for two weeks, with another group ingesting glucose or no sweetener. The dosage was below the acceptable limit. The presence of natural sugars also influenced glycemic responses. Earlier research showed a rapid increase in insulin resistance when sucralose was used with natural carbohydrates.
When mice were transplanted with stool samples from responders, they developed impaired glycemic responses. This was unlike those that received fecal samples from non-responders. This indicates that alterations in the gut microbiome underlie the inability to normalize glucose levels when challenged with a glucose load. This condition would otherwise be referred to as glucose intolerance.
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