Genetic and socioeconomicfactors interact to affect risk of type2diabetes and obesity
The area-level socioeconomic measure most strongly associated with both T2D and obesity was percent without a college degree, and associations with disease prevalence were independent of genetic risk . Moving from lowest to highest quintiles of combined genetic and socioeconomic burden more than tripled T2D and obesity prevalence. Favorable socioeconomic risk was associated with lower disease prevalence, even in those with highest genetic risk .
Additive effects of genetic and socioeconomic factors accounted for 13.2% and 16.7% of T2D and obesity prevalence, respectively, explained by these models. Findings were replicated in independent European and non-European ancestral populations.Genetic and socioeconomic factors significantly interact to increase risk of T2D and obesity. Favorable area-level socioeconomic status was associated with an almost 50% lower T2D prevalence in those with high genetic risk.
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