Iron buildup in brain linked to higher risk for movementdisorders ucsandiego jamaneuro
To what extent does genetic risk for hemochromatosis affect the brain and contribute to risk for neurological disorders?In this cross-sectional study that included 836 participants, we found that individuals at high genetic risk for developing hemochromatosis had magnetic resonance imaging scans indicating substantial iron deposition localized to motor circuits of the brain.
Genetic risk for hemochromatosis is associated with abnormal iron deposition in motor circuits and increased risk of movement disorders, regardless of formal diagnosis of hemochromatosis, and treatment for hemochromatosis that reduces iron overload may prove beneficial for male individuals at genetic risk for hemochromatosis who have movement disorders.Hereditary hemochromatosis is an autosomal recessive genetic disorder that leads to iron overload.
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