AstraZeneca turns its attention to Dublin post-Covid

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AstraZeneca turns its attention to Dublin post-Covid
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Interview: AstraZeneca's Pam Cheng is responsible for bringing the last of the major pharma companies to Ireland. The Anglo-Swedish group never felt the need to invest in manufacturing here. Until now.

More importantly, it had space at its Dublin site.

Cheng, an American chemical engineer by training, is the woman charged with seeing the Irish project to fruition. When it was announced, the Irish investment was painted as a Brexit-inflicted blow to UK Inc. Cheng denies that it was a “direct factor” in the decision and it is true that AstraZeneca continues to invest in its British operations, but she concedes that supply chain and other issues had a bearing in the final call.

Interestingly, while Alexion is very much a biologics operation with stand-alone status in the AstraZeneca group, the new plant that will share its Dublin site is what is known as a small-molecule API plant – a more traditional form of drug.

“This Dublin facility is actually development and commercialisation launch all in the one place,” says Cheng, adding that it allows the company to focus on speed of delivery for a new medicine to the patient. The AstraZeneca manufacturing sites boss was in Dublin last week to unveil the design of the new plant. It is still subject to planning approval but initially, she says, AstraZeneca plans to have the capacity on site for the development and early-stage commercialisation of three drugs simultaneously.

Cheng is confident of delivering the site for regulatory clearance and operations by early 2025, in part, she says, to the “incredibly supportive” IDA Ireland. “Of course, fingers crossed that we don’t get another global pandemic,” she says. “That was incredibly disruptive.” “Covid-19 was the best motivator of all people of all times. I didn’t have to get out there and motivate our troops. People were working above and beyond,” she says. Of the 15,000 people working in AstraZeneca’s global operations division, more than 11,000 came into their plants throughout the pandemic “because we couldn’t make medicine from home”.

“It made everything worthwhile but going through it was not for the faint of heart,” Cheng says, noting that, alongside the Covid vaccine effort, the company also had to keep producing its other medicines. AstraZeneca has also run into problems with its efforts to follow up the success of that first generation of Covid vaccines. The company had high hopes for a nasal version of the vaccine that would have been very easy to apply in multiple settings but it recently failed to deliver the required immune response in an early-stage clinical trial.

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