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The authors thank members of the Kranzusch and Sorek laboratories for helpful discussions. Mass spectrometry was performed at the Biopolymers and Proteomics Core Facility at the Koch Institute of MIT, the Taplin Mass Spectrometry Facility at Harvard Medical School, and the Weizmann De Botton Protein Profiling Institute. We thank W.
This study was supported by the Pew Biomedical Scholars Program , the Burroughs Wellcome Fund PATH award , the Mathers Foundation , the Parker Institute for Cancer Immunotherapy , European Research Council grant ERC-CoG 681203 , Israel Science Foundation grant ISF 296/21 , the Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine , the Minerva Foundation and Federal German Ministry for Education and Research , the Knell Family Center for Microbiology , the Yotam project...