Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes - Genome Biology

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Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes - Genome Biology
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Oxidative phosphorylation complexes are synthesized proportionally across compartments and proportionally to their relative final abundances, according to a study published in GenomeBiology.

], but here we show that, overall, the “correct” number of ribosomes is allocated to each complex when considered as a whole. Instead of each subunit getting an equal share, some get more and some get less, with differential protein turnover having a more prominent role in reaching the final subunit stoichiometry in these complexes . Perhaps this is due to regulatory mechanisms that aid in the assembly of these dual-origin complexes.

Synthesis levels of the least abundant subunit in each complex are not correlated across compartments. OXPHOS complexes display very large differences in half-lives indicating that subunits within already formed and functional complexes are frequently replaced [ ]. Thus, many highly produced subunits could be going into pre-existing complexes rather than being part of de novo complex assembly, resulting in the least produced subunit for each complex not being rate limiting for complex assembly.12

]. However, in that system, synchronous mitochondrial–cytosolic translation programs depend on cytosolic translation, indicating that direct communication between the translation systems enables the coregulation. By contrast, in human cells, mitochondrial synthesis levels do not require ongoing cytosolic translation, at least on the time scale of hours.

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