Biodegradable, Long-Acting Androgenic Alopecia Treatment System tandfmedicine lipidnanoparticles
By Bhavna KavetiSep 27 2022Reviewed by Susha Cheriyedath, M.Sc. The α-reductase inhibitors, including β-sitosterol and phytosterol glycosides, are administered orally to cure androgenic alopecia and promote hair regrowth. However, they have poor bioavailability and solubility.
Incorporating BS-loaded lipid nanoparticles into the chitosan-based MNs resulted in the fabrication of lipid nanoparticle-loaded polymeric MNs. The animal model evaluated the prepared MN-based lipid nanoparticles for androgenic alopecia. The results revealed that the amount of BS associated with MN-based lipid nanoparticles that penetrated the skin of a rat in vitro was 3612.27 ± 120.81 micrograms per square centimeters, while that from lipid nanoparticles alone was 2402.35 ± 162.
In the cells of the hair follicle, testosterone is converted into dihydrotestosterone by the enzyme 5α-reductase that exists as two isoenzymes: type I and type II, and the latter, expressed in the hair follicles and other androgen-dependent tissues, appears to be particularly important in male pattern baldness.
In this regard, to increase the therapeutic effectiveness by enhancing BS oral absorption, complexation with liposomal, cyclodextrin, solid lipid nanoparticles, electrospun nanofibers, and self-emulsion drug delivery systems have all been explored. The effective incorporation of BS in pharmaceutical formulations is a challenging phenomenon.
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