Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease NatureMedicine PittTweet biomarker alzheimers alzheimersdisease AD astrocyte preclinical
By Neha MathurMay 31 2023Reviewed by Lily Ramsey, LLM In a recent article published in Nature Medicine, researchers designed a biomarker study that tested whether astrocyte reactivity modulated the association of amyloid-β with tau phosphorylation in preclinical Alzheimer's disease .
This experimental evidence supports a close link between Aβ, astrocyte reactivity, and tau pathology in preclinical AD. The MYHAT was a population-based study cohort comprising participants from southwestern Pennsylvania in the United States of America , all aged 65+ years. They all completed neuropsychological testing, and CU individuals had clinical dementia rating =0.
In a subset of the TRIAD cohort, they used a mesoscale discovery assay to measure cerebrospinal fluid sTREM2, a microglial marker reflecting an age-dependent increase in microglial senescence. Results and conclusion The authors found biomarkers-based evidence that during preclinical AD, increased astrocyte reactivity was associated with Aβ accumulation during early tau phosphorylation in CU individuals.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
New blood biomarker can predict if cognitively healthy elderly will develop Alzheimer's diseaseWhy do some people develop Alzheimer's disease while others don't? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates—a telltale sign of Alzheimer's brain pathology—never go on to develop Alzheimer's-associated dementias?
Read more »
Alzheimer's blood test could identify disease '10 years' before first symptomsEarly stage Alzheimer's could be diagnosed with a blood test that flags changes in the brain.
Read more »
Champions League and Newcastle United - Startling evidence shows why Premier League big six so upsetThe ChampionsLeague and NUFC - Startling evidence shows why premierleague big six so upset NUFC EPL UCL
Read more »
More Evidence That Monica Bellucci’s Daughter Deva Is The Next Big Thing In ModellingMonica Belluci’s daughter is photographed in Rome and has a striking resemblance to her Italian mother. Click to read about her modelling career to date.
Read more »
Researchers find oldest evidence of the plague in BritainScientists discover 4,000 year-old plague DNA - the oldest evidence of the disease in Britain.
Read more »
Artificial intelligence in sperm selection for assisted reproductionArtificial intelligence in sperm selection for assisted reproduction AI Fertility SpermSelection MachineLearning Infertility Reproductive TechEvolution SpermAnalysis FutureOfFertility ArtificialIntelligence ASRM_org FertStert
Read more »