Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer CommsBio hydrogel hsv1 HSV1 cancer therapy immunotherapy
By Pooja Toshniwal PahariaJun 13 2023Reviewed by Lily Ramsey, LLM In a recent study published in Communications Biology, researchers evaluated the therapeutic efficacy of Navoximod, combined with herpes simplex 1 virotherapy, against hepatocellular carcinoma .
Anti-tumour immunological activation and antiviral immunological suppression must be carefully modulated and balanced to optimize virus-based therapies. The study then explored interferon-stimulated genes that inhibit HSV-1 proliferation to optimize oncolytic immunotherapy based on HSV-1. The team measured HSV-1 deoxyribonucleic acid levels in the nervous system, blood, and peripherally located organs following subcutaneous hydrogel injections to assess their cytotoxicity.
Of note, the hydrogel extended the disease-free life period of mice with HCC, protected them against tumour recurrence, and was effective in the rabbit orthotopic hepatic tumour model. Mechanistically, HSV-1 virotherapy and IDO1 inhibition, when combined, entirely reprogrammed the tumour microenvironment via scRNA sequencing.
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