Automated insulin dosing systems combine low-cost blood-glucose monitors with insulin pumps that use precision dosing to continuously regulate blood-sugar and hold it steady. Synthetic biologists have found a way to piggyback on the technology and make it universally applicable for the precision dosing of virtually any drug.
Rice University synthetic biologists have found a way to piggyback on the glucose monitoring technology used in automated insulin dosing systems and make it universally applicable for the monitoring and dosing of virtually any drug., researchers in the lab of Caroline Ajo-Franklin demonstrated the technique by modifying a blood-glucose sensor to detect the anticancer drug afimoxifene , an estrogen inhibitor that patient's bodies also make after they take the chemotherapy tamoxifen.
The heart of blood-glucose monitoring technology is a biochemical reaction in which specific proteins bind to glucose molecules and release electrons. Millions of these reactions take place within seconds, creating a small electrical current that is proportional to the amount of glucose in the blood sample.
Ajo-Franklin said her lab is already working on both ways to improve the sensitivity of glucose-based drug tests and methods to rapidly identify glucose-oxidizing proteins that can detect drugs other than afimoxifene. Rong Cai, Chiagoziem Ngwadom, Ravindra Saxena, Jayashree Soman, Chase Bruggeman, David P. Hickey, Rafael Verduzco, Caroline M. Ajo-Franklin.New research shows that automated insulin delivery technology could be a game changer for pregnant women with type 1 diabetes. The technology -- known as 'hybrid closed-loop technology' -- gives ...
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