Breast cancer spreads more aggressively during sleep

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Breast cancer spreads more aggressively during sleep
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Many more cancerous cells circulate in the blood at night, suggesting that time of day could play a role in diagnosis and treatment

, such as those of flight attendants and night nurses, as “probably carcinogenic.”

“Immune cells also have circadian clock, and their function shows daily fluctuations,” says Kazuhiro Yagita, a doctor of internal medicine at Kyoto Prefectural University of Medicine, Japan.peak during the rest phase: nights for humans and day for mice That is why it comes as a surprise to scientists that key circadian rhythm hormones such as melatonin and testosterone directly affected the dynamics of CTC generation in the Zurich study.When scientists noticed discrepancies in the number of cancer cells detected in blood samples collected at different times from cancer patients, they were motivated to investigate further, Aceto says.

During the resting phase, the cancer cells that were released divided more rapidly than healthy cells. These cells were also more likely to grow into new tumors, suggesting that CTCs breaking away during sleep were somehow better at metastasis.

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