Calorie restriction and therapy combo reshapes gut microbiome, boosts mental health in women

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Calorie restriction and therapy combo reshapes gut microbiome, boosts mental health in women
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Study finds that combining caloric restriction with psychological interventions significantly alters the gut microbiome and improves stress-related mental health in women.

By Vijay Kumar MalesuReviewed by Benedette Cuffari, M.Sc.Aug 11 2024 In a recent study published in the journal Nutrients , researchers investigate the combined effects of caloric restriction and clinical psychological intervention on the composition of the gut microbiome and stress-related mental health outcomes in women.

About the study The study cohort comprised 41 women who completed two weeks of inpatient lifestyle intervention at the La Pura Women’s Health Resort. The intervention involved a combination of dietary CR and CPI. Clinical variables included age, body mass index , morning cortisol, C-reactive protein , and interleukin 6 . Psychometric outcomes were assessed using the Brief Symptom Index , the Perceived Stress Scale , and the burnout dimension inventor . Fasting blood and stool samples were collected at baseline and follow-up for microbial analysis through 16S ribosomal ribonucleic acid sequencing.

Related StoriesThe multilevel principal component analysis revealed a separation between baseline and follow-up samples, with FXM samples clustering further along the negative scale of the first principal component . Oscillospira was negatively associated with PC1, while Agathobacter, Subdoligranulum, E. xylanophilum, Fusicatenibacter, E. ventriosum, Roseburia, UCG-002, and Faecalibacterium were positively associated.

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