Imbalances in blood-cell production could affect disease outcome.
). The development and progression of cardio-vascular disease could be influenced by a perturbation in the balance of haematopoiesis, the process by which blood cells are generated from haematopoietic stem and progenitor cells .
Indeed, inflammatory blood cells that are derived from haematopoietic progenitor cells in the bone marrow have been implicated in cardiovascular disorders such as athero-sclerosis, a condition in which cholesterol builds up in the arteries; myo-cardial infarction ; and ischaemia, a form of heart failure that results from a lack of oxygen supply . This relationship between the cardiac and haemato-poietic systems was thought to be unidirectional.
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