Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia sjtu1896 AML AcuteMyeloidLeukemia Protein Characterization
By Tarun Sai LomteFeb 2 2023Reviewed by Aimee Molineux In a recent study posted to Preprints with The Lancet*, researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia patients with a mutant Ikaros zinc finger protein 1 .
The study and findings In the present study, researchers explored the mutation landscape of IKZF1 in a large Chinese AML cohort. Primary blasts were collected from the bone marrow of 475 patients with AML having at least 20% abnormal blasts. RNA sequencing and targeted screening of common leukemia-associated genes were performed. FLAG-tagged wild-type or mutant IKZF1 was expressed in the K562 cell line.
Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Gene set enrichment analysis revealed that B-cell receptor, tumor-growth factor -beta, MYC, NOTCH, MYC-associated factor X , vascular endothelial growth factor , and mitogen-activated protein kinase were upregulated in N159S-positive AML patients. At the same time, nucleotide excision and DNA mismatch repair pathways were downregulated.
More wild-type and G158S-positive cells were arrested in the G1 phase of the cell cycle than N159S/Y-positive cells. Further, cell growth and differentiation were significantly inhibited in G158S and wild-type cells relative to N159S/Y cells, suggesting that N159S might disturb Ikaros’ normal function, induce apoptosis, and inhibit cell cycle and proliferation of leukemic cells.
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