The event is due to be held with an audience for the first time since the Covid-19 pandemic
BBC News
The event is due to take place on 19 December at All Saints with Holy Trinity church in Loughborough. Music will come from Charnwood Symphonic Wind Orchestra with performances from Corah, a Leicester-based female vocal ensemble, and the All Saints church choir.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines - Genome MedicineBackground COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hyperinflammatory responses in severe COVID-19 patients. Methods In this study, we obtained the DNA methylome and transcriptome of peripheral blood monocytes from severe COVID-19 patients. DNA samples extracted from CD14 + CD15- monocytes of 48 severe COVID-19 patients and 11 healthy controls were hybridized on MethylationEPIC BeadChip arrays. In parallel, single-cell transcriptomics of 10 severe COVID-19 patients were generated. CellPhoneDB was used to infer changes in the crosstalk between monocytes and other immune cell types. Results We observed DNA methylation changes in CpG sites associated with interferon-related genes and genes associated with antigen presentation, concordant with gene expression changes. These changes significantly overlapped with those occurring in bacterial sepsis, although specific DNA methylation alterations in genes specific to viral infection were also identified. We also found these alterations to comprise some of the DNA methylation changes occurring during myeloid differentiation and under the influence of inflammatory cytokines. A progression of DNA methylation alterations in relation to the Sequential Organ Failure Assessment (SOFA) score was found to be related to interferon-related genes and T-helper 1 cell cytokine production. CellPhoneDB analysis of the single-cell transcriptomes of other immune cell types suggested the existence of altered crosstalk between monocytes and other cell types like NK cells and regulatory T cells. Conclusion Our findings show the occurrence of an epigenetic and transcriptional reprogramming of peripheral blood monocytes, which could be associated with the
Read more »
Hong Kong battles to stem brain drain following China's crackdown and Covid restrictionsOnce dubbed a 'shining city on the harbour', Hong Kong has seen a mass exodus amid strict Covid rules and a crackdown on freedoms, leaving city officials with the dilemma of how to attract new talent
Read more »
China eases some COVID restrictions following anti-lockdown protestsWhile restrictions are being eased in some cities, health experts and economists expect the zero-COVID strategy to stay in place at least until mid-2023 and possibly into 2024.
Read more »
Matt Hancock slammed for 'deluded' diary of Covid pandemicMatt Hancock has been condemned as ‘deluded’ over his memory of how he handled care homes during the pandemic. Read more here 👇
Read more »