Circulating serum metabolites measured in midlife make only a modest contribution to dementia prediction once age is taken into account, according to a study published in BMCMedicine.
]. Explicit consideration of age in our algorithm to identify putative biomarkers was ensured by selecting sets of metabolites that improved predictive accuracy compared to an age-only model. This was achieved by constructing risk scores, constituted first using age alone and subsequently using age along with selected metabolites in order to test whether metabolites improved dementia prediction over and above the effect of age.
The association between 1 SD increment in each metabolite, analysed individually, and incident dementia was examined using Cox regression. The start of follow-up was the date of the 1997–1999 clinical examination, and participants were censored at date of dementia diagnosis, death, or 31st of March 2019, whichever came first.
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