Renin-angiotensin-aldosterone system inhibitor (RAASi) discontinuation or down-titration after an episode of hyperkalemia is associated with a higher risk of cardiorenal events compared with maintained RAASi, finds a study published in BMCNephrol
Previous research has focused on the clinical impact of not achieving maximum RAASi dose, without necessarily accounting for the underlying rationale and that some patients may not tolerate the maximum dose due to adverse effects unrelated to HK.
Patient-level changes in RAASi treatment following the HK episode were described according to the dose in the most recent prescription filled within 90 days after the index episode of HK relative to their most recent dose prior to the index HK episode. Patients were categorized as having maintained or up-titrated their dose, down-titrated their dose of any previously prescribed RAASi agent by > 25%, or discontinued .
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