It's in a bid to reduce carbon emissions
Councillors greenlit the siwtch on Thursday night following the results of a summer trial.
“The transition to move our fleet to this high quality, liquid fuel is really encouraging. HVO is stable and renewable whilst significantly reducing greenhouse gas emissions on combustion. . Bin lorries will also be included in the transition, which involves around 200 vehicles or 88% of the diesel fleet.
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Notts man called police 68 times in 90 minutes while drunk in bedAs the force approaches it busiest time of the year, Nottinghamshire Police has issued a plea for people to use 999 responsibly after a recent spate of incidents.
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A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX) - Journal of Neurodevelopmental DisordersBackground Fragile X syndrome (FXS) is associated with dysregulated endocannabinoid signaling and may therefore respond to cannabidiol therapy. Design CONNECT-FX was a double-blind, randomized phase 3 trial assessing efficacy and safety of ZYN002, transdermal cannabidiol gel, for the treatment of behavioral symptoms in children and adolescents with FXS. Methods Patients were randomized to 12 weeks of ZYN002 (250 mg or 500 mg daily [weight-based]) or placebo, as add-on to standard of care. The primary endpoint assessed change in social avoidance (SA) measured by the Aberrant Behavior Checklist–Community Edition FXS (ABC-CFXS) SA subscale in a full cohort of patients with a FXS full mutation, regardless of the FMR1 methylation status. Ad hoc analyses assessed efficacy in patients with ≥ 90% and 100% methylation of the promoter region of the FMR1 gene, in whom FMR1 gene silencing is most likely. Results A total of 212 patients, mean age 9.7 years, 75% males, were enrolled. A total of 169 (79.7%) patients presented with ≥ 90% methylation of the FMR1 promoter and full mutation of FMR1. Although statistical significance for the primary endpoint was not achieved in the full cohort, significant improvement was demonstrated in patients with ≥ 90% methylation of FMR1 (nominal P = 0.020). This group also achieved statistically significant improvements in Caregiver Global Impression‐Change in SA and isolation, irritable and disruptive behaviors, and social interactions (nominal P-values: P = 0.038, P = 0.028, and P = 0.002). Similar results were seen in patients with 100% methylation of FMR1. ZYN002 was safe and well tolerated. All treatment-emergent adverse events (TEAEs) were mild or moderate. The most common treatment-related TEAE was application site pain (ZYN002: 6.4%; placebo: 1.0%). Conclusions In CONNECT-FX, ZYN002 was well tolerated in patients with FXS and demonstrated evidence of efficacy with a favorable benefit risk relationship in patients with ≥ 90% methylation o
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Lancashire County Council posts urgent recall on a baby product which can cause harm and deathLancashire County Council have shared an urgent product recall of a device which could cause serious harm to babies.
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Greater Manchester council invested up to £10m with Qatar National BankThe authority deposited between £5m and £10m with the state lender during various periods
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Family spend 5 years stuck in mould-ridden temporary house after council ignored pleas to moveA family of three that has been trapped living in squalid conditions for five years has been moved to new accommodation after i contacted the council
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Autistic man branded 'narcissistic psychopath' was 'failed' by Yorkshire councilA Yorkshire council showed a “significant lack of understanding” of the needs of people with autism according to a scathing new investigation.
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