Mark Stoneman scores 115 as Middlesex total 358 and reduce Derbyshire to 74-3 at stumps, still 111 behind.
Middlesex are on track for the win they need to keep their County Championship promotion challenge alive going into the final week of the season after maintaining their dominance over bottom-of-the-table Derbyshire.
Needing 186 to make Middlesex bat again, Derbyshire lost two wickets in the first five overs of their second innings and another from the last ball of the day to close on 74-3. Middlesex banked maximum bowling bonus points on day one and had looked well placed at 125-1 overnight to push for a full set of batting points.
Leus Du Plooy was struck in front on 11 by off-spinner Alex Thomson, who then bowled Ryan Higgins for four.
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