COVID-19 infection is associated with an elevated risk for incident cardiovascular disease events and death compared with those with no history of COVID-19, a retrospective analysis shows.
death, VTE, all-cause mortality, pericarditis, cardiovascular mortality, MI, AF, heart failure, and stroke were all among the incident outcomes assessed. Over a mean prospective follow-up period of 141 days, the researchers estimated the relationships between COVID-19 and each outcome using Cox proportional hazards regression.
Finally, among patients hospitalized for other issues and found to have COVID-19 as a secondary diagnosis , there was an increased risk for all incident outcomes compared with those without infection. While their risk for all-cause death was lower than for those hospitalized primarily for COVID-19, the risk for death from cardiovascular or ischemic heart disease was higher, as was incident MI and AF risk.
More investigation is needed to determine the timeframe over which cardiovascular risk is elevated after COVID-19, the study authors noted. "The prothrombotic effects of COVID-19 do raise the question of whether antithrombotic strategies are required to prevent this large excess of events."
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