COVID-19 vaccination reduced the severity of the Omicron-driven pandemic wave in Saudi Arabia SARSCoV2 COVID19 Omicron Variant Vaccine Vaccination
By Neha MathurOct 14 2022Reviewed by Aimee Molineux In a recent study published in the Journal of Infection and Public Health, researchers conducted a retrospective study of all coronavirus disease 2019 cases from a single hospital in the Kingdom of Saudi Arabia between December 25, 2021, and February 30, 2022.
Although compared to Delta, Omicron caused less severe infections, fewer hospitalizations, intensive care unit admissions, and much-reduced mortality, there was an urgent need to evaluate its effects in the general population. A binary logistic regression analysis helped the researchers model multiple covariates with admission status and gender. Furthermore, they constructed a Boxplot of the cycle threshold values of SARS-CoV-2 reverse transcriptase-polymerase chain reaction with COVID-19 vaccine doses. Finally, the team used Kaplan-Meier curve analysis to determine the days from the last COVID-19 vaccine to the subsequent occurrence of SARS-CoV-2 infection.
The most common symptoms observed in the study of patients infected with Omicron were sore throat, cough, fever, and headache, observed in 39.8%, 39.5%, 33%, and 30.5% of patients, respectively. The clinical presentation and comorbidities did not change with the patient's gender during the Omicron-driven pandemic wave. However, the occurrence of sore throat in a binary logistic regression showed a higher rate among males with an OR of 2.014.
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