Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development MultipleSclerosis EpsteinBarr EBVInfection AntibodyResponse CRYABPeptide ImmuneResponse Immunology ScienceAdvances
By Bhavana KunkalikarMay 21 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Science Advances, researchers explore the association between cross-reactive immunity to Epstein-Barr virus nuclear antigen 1 and multiple sclerosis .
EBV infection, for example, is considered to be risk factor and prerequisite for a diagnosis of MS. Like MS, EBV also arises due to both genetic and environmental risk factors. Although more than 90% of the global population has likely been infected with EBV, only a small portion of individuals will subsequently develop MS.
About the study Plasma samples from 713 MS and 722 control participants were obtained from the Swedish nationwide Epidemiological Investigation of an MS cohort. The controls in the study were selected based on population and were matched to MS patients by sex, age, and geographic area. Related StoriesCRYAB antibodies were similar in individuals with relapsing-remitting, secondary progressive, and primary progressive MS. Age, disease duration, and sex also did not impact anti-CRYAB reactivity.
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Associations between dietary patterns and an array of inflammation biomarkers and plasma lipid profile in postmenopausal women - BMC Women's HealthObjective and design In this cross-sectional study, evaluation of the association between four dietary patterns, nutrients and food intakes and an array of systemic inflammation biomarkers and lipid profile among 80 New Zealand postmenopausal women were conducted. Materials Eighty postmenopausal women participated in the study. A validated food frequency questionnaire was used to collect nutrients and food intake. Four dietary patterns were identified by principal component analysis (PCA) and plasma samples collected for inflammatory biomarkers and lipid profile measures. Results There were negative correlations between intake of dietary fibre, soluble and insoluble non-starch polysaccharides (NSP), vitamin C and niacin and with almost all the inflammatory markers for the whole group. Vegetables, tea/coffee and especially fruit intake were negatively correlated with the inflammatory biomarkers in the whole group. A high intake of Pattern 1 (potato, bread, and fruit pattern) was associated with a low risk of high interferon (IFN)-α2, IFN-λ, interleukin (IL)-6 and IL-8 levels while a high intake of Pattern 3 (fast-food pattern) was associated high risk of IFN-α2 levels. Multiple linear regression showed a negative correlation between Pattern 2 (soups and vegetables pattern) and levels of C-reactive protein (CRP) as well as ferritin. A positive association was observed between Pattern 3 (fast-food pattern) and CRP levels. Positive correlation was also observed between Pattern 2 and high-density lipoprotein (HDL) and total cholesterol (TC) levels, Pattern 4 (meat and vegetables pattern) was however negatively correlated with TC, low-density lipoprotein (LDL) and TC/HDL ratio. Conclusions The result of this study reinforces the contribution and role of diet in modifying inflammation in postmenopausal women.
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