The Crystal Bone novel algorithm predicted 2-year risk of osteoporotic fractures in a large dataset with an accuracy that was consistent with FRAX 10-year risk predictions, researchers report. ASBMR2022
Invited to comment, Peter R. Ebeling, MD, outgoing president of the ASBMR, noted that"many clinicians now use FRAX to calculate absolute fracture risk and select patients who should initiate anti-osteoporosis drugs."
"This is a very useful advance," Ebeling summarized,"in that it would alert the clinician to patients in their practice who have a high fracture risk and need to be investigated for osteoporosis and initiated on treatment. Otherwise, the patients would be missed, as currently often occurs." Compston, emeritus professor of bone medicine, University of Cambridge, UK, who was not involved with the research but who also disclosed being a consultant for Amgen, selected the study as one of the top clinical science highlights abstracts at the meeting.
"The Crystal Bone algorithm offers the potential for fully automated population-based screening in older adults to identify those at high risk of fracture, for whom effective therapies are available to reduce fracture risk," she summarized.
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