A Review in Translational Neurodegeneration summarizes the evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urges developing tools for lysosomal pH monitoring and detection.
Schematic representation of lysosomal acidification modulation by small molecules and lysosome-targeting nanomedicine.Cyclic adenosine monophosphate and NKH-477 increase the intracellular content of cAMP, which is essential for maintaining lysosomal acidification.Targeting ion channels, such as activating TRPML1 by SF-22 and inhibiting TPC2 by tetrandrine, allows for a balance of ions in the lysosome lumen to maintain lysosomal acidification.
Ps and AcNPs; PaNPs and acidic NL-NEs have not been characterized. Ps, Poly NPs; AcNPs, Acidic NPs; PaNPs, Photo-activated NPs; Acidic NL-NEs, Acidic nucleolipid nanoemulsions; LA, Lactic acid; GA, Glycolic acid; TFSA, Tetrafluorosuccinic acid; SA, Succinic acid. Schematics were created by BioRender and chemical structures were drawn by ChemDraw.
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The relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome - Journal of Translational MedicineBackground Post-COVID-19 syndrome (PCS) shares many features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PCS represents a major health issue worldwide because it severely impacts patients’ work activities and their quality of life. In the absence of treatment for both conditions and given the beneficial effect of pacing strategies in ME/CFS, we conducted this study to assess the effectiveness of pacing in PCS patients. Methods We retrospectively included patients meeting the World Health Organization definition of PCS who attended the Internal Medicine Department of Angers University Hospital, France between June 2020 and June 2022, and were followed up until December 2022. Pacing strategies were systematically proposed for all patients. Their medical records were reviewed and data related to baseline and follow-up assessments were collected. This included epidemiological characteristics, COVID-19 symptoms and associated conditions, fatigue features, perceived health status, employment activity, and the degree of pacing adherence assessed by the engagement in pacing subscale (EPS). Recovery was defined as the ability to return to work, and improvement was regarded as the reduction of the number and severity of symptoms. Results A total of 86 patients were included and followed-up for a median time of 10 [6–13] months. Recovery and improvement rates were 33.7% and 23.3%, respectively. The EPS score was the only variable significantly associated with recovery on multivariate analysis (OR 40.43 [95% CI 6.22–262.6], p | 0.001). Patients who better adhered to pacing (high EPS scores) experienced significantly higher recovery and improvement rates (60–33.3% respectively) than those with low (5.5–5.5% respectively), or moderate (4.3–17.4% respectively) scores. Conclusion Our findings demonstrated that pacing is effective in the management of patients with PCS, and that high levels of adherence to pacing are associated with better outcomes.
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Impaired histone inheritance accelerates breast cancer growth and metastasis, study showsChromatin states and their associated epigenetic information play a crucial role in maintaining the identity of cells as they divide. Histone post-translational modifications (PTMs) are important determinants of the cellular epigenetic state, carrying epigenetic information and regulating gene transcription.
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The COVID-19 Vaccine Is Getting an Update. Here's What to KnowExperts were still divided over how often the COVID-19 vaccine should be given in the U.S. They noted that there is no definitive data showing that SARS-CoV-2 follows a seasonal pattern
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Graeme Souness is fundraising for DEBRA'I've never been the weakest link in a team, but in this team I am by a country mile!' 'This disease is the worst thing I've ever seen.' 💔 Graeme Souness shares why he is swimming the English Channel for DEBRA. 👏 To donate:
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Vitreous Humor Biomarkers Reflect Pathological Changes in the Brain for Alzheimer’s Disease and Chronic Traumatic Encephalopathy - IOS PressBackground: Patients with eye disease have an increased risk for developing neurodegenerative disease. Neurodegenerative proteins can be measured in the eye; however, correlations between biomarker levels in eye fluid and neuropathological diagnoses
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Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical studyScientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer's and multiple sclerosis. The study was recently published in Advanced Science.
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