Researchers led by the Beth Israel Deaconess Medical Center, Boston, have examined how a dementia diagnosis impacts medication use patterns in older adults.
. Existing clinical guidelines recommend tailoring treatments based on comorbidities, potential benefits, and patient goals. The impact of a dementia diagnosis on medication use patterns and deprescribing is not understood.
The study analyzed 266,675 adults with incident dementia and 266,675 as a control from a national sample of Medicare Part D beneficiary pharmacy claims from 2010 to 2019. New incident dementia cases were identified using validated diagnosis codes. Patients with dementia were matched with controls based on various demographic and medication-related factors.
There was an unexpected increase in central nervous system-active medications following a dementia diagnosis. This contradicts professional guidelines and raises concerns, as these medications can adversely affect cognitive function and are not typically recommended. Many CNS-active medications have been identified as potentially inappropriate due to their association with increased risk of falls, worsening cognitive function, and other adverse drug events.
Some cardiometabolic medications, like antihypertensives and insulins, immediately increased use following
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