An article published in BCRJournal presents PDxBr: a digital AI-based breast cancer test to predict the risk of early-stage breast cancer recurrence.
], we employ a supervised pathologist driven feature design process. The result is readily explainable features for pathologists and oncologists, appropriate for risk modeling and potential predictive response. We then combined the AI grade with clinical features such as the patients’ age, tumor size, stage and number of positive lymph nodes to generate the PDxBr risk score to categorize patients as low or high risk for BC recurrence within 6 years of a definitive treatment .
Validation of the PDxBr model produced a C-index of 0.75 versus optimized clinical or imaging models of 0.71 and 0.67, respectively. Using a validated risk score to discriminate low versus high risk yielded an HR of 4.4 with an NPV of 94. The data suggest that with an NPV of 94% and a PPV of 24%, due to the lower prevalence of events in this low-risk cohort, the PDxBr would potentially be effective in combination with oncotype RS and other gene expression tests to rule-out chemotherapy.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Further 1,500 patients of breast surgeon Ian Paterson to be recalledPaterson is known to have treated thousands at Spire Parkway hospital and Spire Little Aston hospital in the West Midlands between 1997 and 2011.
Read more »
Another 1,500 patients of jailed breast surgeon Ian Paterson being recalledPaterson subjected more than 1,000 patients to unnecessary operations over 14 years and an inquiry ruled he was free to perform harmful surgery due to a 'culture of avoidance and denial'.
Read more »
EA cancels development of Apex Legends Mobile, Battlefield MobileEA has announced the cancellation of Apex Legends Mobile and Battlefield Mobile, as well as the closure of developer In…
Read more »
Housebuilder to release last of homes at popular developmentA HOUSEBUILDER is set to release its final collection of homes at a popular development in Newton Mearns.
Read more »
EA is cancelling Apex Legends Mobile and Battlefield Mobile | VGCElectronic Arts is ending support for Apex Legends Mobile and cancelling Battlefield Mobile before its official release. It’s also closing Industrial Toys, the mobile studio headed by Bungie founder Alex Seropian
Read more »
81 new affordable homes unveiled at former engineering firm baseThese fantastic new homes will benefit many local people and families for years to come
Read more »