The drug metformin, widely used to treat diabetes, may cause genital birth defects in the male children of men who take the medication, researchers have found.
For the new study, Eisenberg and his colleagues analyzed records in a database of all 1.25 million births that occurred in Denmark between 1997 and 2016. The database included information on birth defects and parents’ drug prescriptions.
Children were considered exposed to a diabetes drug if a father had filled one or more prescriptions for the medications during the 3 months prior toThe final analysis included over one million children, of whom about 7,000 were exposed to diabetes drugs via the father, and about 36,000 had one or more major birth defects.
Among nearly 1,500 male children whose fathers had taken metformin, there were 3.4-times as many major birth defects of the genitals and urinary tract, according to the researchers. The researchers did not find significant associations between birth defects and the use ofThe researchers didn’t find a risk of birth defects for the children of men who were prescribed metformin in the year before or after their fertilizing sperm developed.
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