New, precise, and efficient DNA sequencing method may lead to easier testing and earlier cancer detection pennmedicine nchembio
pG sequencing contexts given the known GpC preference for M.CviPI. The enzyme has known off-target and heterogenous activity at CppG sites. The dashed line shows the readout if BS-Seq signal inversely correlates with DM-Seq as anticipated.Comparison of BS-Seq and DM-Seq modification status by 5’ sequence context. The box shows the lower quartile, median, and upper quartile. Minimum and maximum values are shown by the whiskers.
The sample with TET and bisulfite indicates efficient conversion of 5mC to 5fC/5caC by TET.Proportion of reads mapping to each spike-in are shown. Borane deamination shows decreased reads mapping to the methylated lambda phage, with depletion dependent upon TET oxidation.qPCR detection of amplifiable DNA library after each deamination method. Shown are the p-values from paired two-tailed t-test . Data are presented as mean values +/− SD.
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