Economically disadvantaged neighborhoods in Austin, Texas saw higher rates of infection well into pandemic's second year utaustin
Conceptualization, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editingDepartment of Epidemiology & Biostatistics, University of Georgia, Athens, Georgia, United
States of America, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America, Center for the Ecology of Infectious Diseases, University of Georgia, Athens, Georgia, United States of America
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Effects of serum sodium and chloride levels in the outcome of critically ill pediatric patients in the post-operative period of liver transplantation - BMC NephrologyBackground Sodium and chloride disturbances have attracted increasing attention in recent years. Many pathophysiological effects are associated with hyperchloremia, including reduction in mean arterial pressure and acute renal disease. Pediatric patients undergoing liver transplantation are at risk of developing various electrolyte and biochemical abnormalities, with an impact on their postoperative outcomes. Objective To analyze the impacts of serum sodium and chloride levels on prognosis of Pediatric Liver Transplant receptors. Methods This was a retrospective analytical observational study performed in a single transplant reference center in Sao Paulo, Brazil. Included patients were pediatric patients who underwent liver transplantation between January 2015 and July 2019. Statistical regression analysis and General Estimating Equations analysis were performed to evaluate the impacts of sodium and chloride disturbances on the development of acute renal failure and mortality. Results A total of 143 patients were included in this study. The main diagnosis was Biliary Atresia (62.9%). Twenty-seven patients died (18.9%), and graft dysfunction was the main cause of death (29.6%). The only variable individually associated with 28-days mortality was PIM-3 score (HR 1.59, CI 95% 1.165–2.177, p = 0.004). Forty-one patients (28.6%) developed moderate or severe AKI. PIM-3 score (OR 3.052, 95% CI 1.56–5.97, p = 0.001), hypernatremia (OR 3.49, 95% CI 1.32–9.23, p = 0.012), and hyponatremia (OR 4.24, 95% CI 1.52–11.85, p = 0.006) were independently associated with the development of moderate/severe AKI. Conclusions In pediatric patients after liver transplantation, PIM-3 score, and abnormal serum sodium levels were correlated with AKI development.
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Boris Johnson hands over unredacted WhatsApp messages and notebooks to Cabinet Office for Covid inquiryBoris Johnson has handed over all requested materials, including unredacted WhatsApp messages and his notebooks, to the Cabinet Office for the Covid inquiry.
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Boris Johnson says he has handed over Covid WhatsAppsThe inquiry into the pandemic is demanding the government release the unredacted messages by Thursday.
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Boris Johnson gives Covid Whatsapps to Cabinet Office and wants them handed to inquiry urgently🔴 Breaking: Boris Johnson has handed all of his WhatsApp messages and notebooks from when he was prime minister to the Cabinet Office in “full and unredacted” form, and has urged the government to cooperate with the Covid inquiry “urgently”
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