visionary curators Jayden Ali, Joseph Henry, Meneesha Kellay, and Sumitra Upham, unveil an exhibition at the 18th International Architecture Exhibition of La Biennale di Venezia 2023
The British Council has been responsible for the British Pavilion at the International Art and Architecture Exhibitions organised by La Biennale di Venezia since 1937, showcasing the best of the UK's artists, architects, designers and curatorsPREPARE TO be captivated as the British Council, in collaboration with visionary curators Jayden Ali, Joseph Henry, Meneesha Kellay, and Sumitra Upham, unveils an extraordinary exhibition at the prestigious 18th International Architecture Exhibition of...
Prepare to be awestruck by the breathtaking spectacle of a colossal futuristic domino meticulously carved from ash timber, standing alongside an awe-inspiring ‘bone temple’ crafted with the finest textiles. At the heart of this transcendent experience lies a celebration of the transformative rituals observed across the globe.
Accompanied by a meticulously curated soundtrack composed by Oscar #Worldpeace and Fredwave, the cinematic narrative transports viewers on a sublime audiovisual journey, seamlessly blending the past and present.
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Venice beyond La Biennale: the ultimate 21st century international villageWe tour Venice with architect, researcher and curator Federica Sofia Zambeletti, who shows us around Italy’s precious lagoon city – just in time for the launch of the Venice Architecture Biennale 2023
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Sex differences in the polygenic architecture of hearing problems in adults - Genome MedicineBackground Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predisposition. Although several risk loci have been already identified, HP biology and epidemiology are still insufficiently investigated by large-scale genetic studies. Methods Leveraging the UK Biobank, the Nurses’ Health Studies (I and II), the Health Professionals Follow-up Study, and the Million Veteran Program, we conducted a comprehensive genome-wide investigation of HP in 748,668 adult participants (discovery N = 501,825; replication N = 226,043; cross-ancestry replication N = 20,800). We leveraged the GWAS findings to characterize HP polygenic architecture, exploring sex differences, polygenic risk across ancestries, tissue-specific transcriptomic regulation, cause-effect relationships with genetically correlated traits, and gene interactions with HP environmental risk factors. Results We identified 54 risk loci and demonstrated that HP polygenic risk is shared across ancestry groups. Our transcriptomic regulation analysis highlighted the potential role of the central nervous system in HP pathogenesis. The sex-stratified analyses showed several additional associations related to peripheral hormonally regulated tissues reflecting a potential role of estrogen in hearing function. This evidence was supported by the multivariate interaction analysis that showed how genes involved in brain development interact with sex, noise pollution, and tobacco smoking in relation to their HP associations. Additionally, the genetically informed causal inference analysis showed that HP is linked to many physical and mental health outcomes. Conclusions The results provide many novel insights into the biology and epidemiology of HP in adults. Our sex-specific analyses and transcriptomic associations highlighted molecular pathways that may be targeted for drug developme
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