National Highways is issuing the advice ahead of the four-day festival, which attracts around 100,000 people.
Fans heading to Download have been advised to observe road diversions as they travel to the rock festival.
The event will be marking its 20th anniversary and the 2023 event will be the first time the festival has hosted four headline sets.Metallica are to play two headline sets, while Bring Me The Horizon will headline the Friday night and Slipknot will bring the event to a close. The organisation said there would be just one arrival day before the event got under way, due to there being an extra day of live music this year.
National Highways' network resilience planner Phil Shaw said: "We expect the M1, A42, A50 and A38 to see significant increases in traffic over the festival period, particularly when everyone arrives on the Wednesday and again when they leave on Monday.
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