Ebola and COVID-19 have confirmed that staying on top of any virus’s changes as they occur are critical to controlling it, Dr. Pardis Sabeti says. With the power of genetic sequencing, the battle against pathogens “is ours to lose now'
f you want to join Pardis Sabeti’s lab, or collaborate with her on a scientific project, you have to be ready to keep up. Sabeti, an MD, PhD, and tenured professor in center for systems biology at Harvard, and a member of the Broad Institute of Harvard and MIT, solves big scientific problems in only one gear: fast forward.
When the Ebola outbreaks struck west Africa in 2014, Sabeti and her team developed a way to quickly sequence the genomes of viruses, and analyze them to determine where and how quickly they spread in a population. That real-time information was crucial to helping public health experts formulate the right guidelines for containing the spread of Ebola, such as noting that the strains were jumping predominantly from person to person and no longer from animals to people.
Sabeti and her team were championing real-time genetic sequencing long before it was accepted in the scientific world. “I find myself oftentimes in a place where I see and say things that people react to strongly until they become intuitive,” she says. Some of this, she attributes to gender bias. “It’s a constant battle. Every day I’m reminded that I’m not supposed to be here, that I’m a nobody, impertinent — all kinds of things,” she says. “I was told when COVID-19 hit to ‘Sit this one out.
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