Drug combo breaks down cancer resistance to immunotherapy epfl_en ImmunityCP
Nonetheless, many patients either don't respond to immunotherapy, or if they do, the effects are temporary, which highlights how crucial it is that we better understand the mechanisms leading to cancers resisting this kind of treatment.
In a new study, scientists have found a way to break down the resistance of mice with neuroendocrine pancreatic cancer. This cancer is very resistant to a type of immunotherapy called, where the patient receives a drug that blocks proteins that normally keep immune responses from being too strong, but can also prevent immune cells from killing cancer cells.
The study was led by the group of Douglas Hanahan at EPFL's Swiss Institute for Experimental Cancer Research, with the Ludwig Institute for Cancer Research, the Lausanne University Hospital , the Swiss Institute for Bioinformatics, and Roche. The scientists evaluated a type of engineered protein-antibody fusion called an immunocytokine, which is increasingly used in immunotherapy. They focused on the bispecific immunocytokine PD1-IL2v, which is newly developed by Roche and can home in on tumors, wherein it activates killer T cells to attack the
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