The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.
"The NDV-HXP-S vaccine induced neutralizing antibody responses against wild type SARS-CoV-2 that matched what we see after mRNA vaccination, but the proportion of neutralizing antibodies in the response was higher for NDV-HXP-S," said Mount Sinai's Florian Krammer. The vaccine can be manufactured like flu vaccines at low cost in chicken eggs at influenza vaccine manufacturing plants around the world, his team said.
Their "Prime and Spike" strategy employs a booster vaccine currently being tested in animals. In mice with waning immunity after two doses of the Pfizer/BioNTech shot, the purified spike protein vaccine strongly boosted first- and second-line immune responses to the virus in the nose, lungs and blood and protected against lethal doses of the virus, researchers reported onahead of peer review.
"This strategy is likely to confer long-lasting and cross-reactive memory that can be quickly restimulated to prevent viral spread," study leader Akiko Iwasaki of Yale University explained on Twitter. "The intranasal spike protein booster will also be much easier to administer ... and is much more likely to be accepted by people who are hesitant of mRNA or those with needle phobia.
The findings are reassuring, researchers say, because poor outcomes might rule out these patients' transplant eligibility even if their lungs were completely destroyed, given the shortage of available organs. From August 2020 through September 2021, 3,039 lung transplants were performed in the United States, 7% of which were done in COVID-19 survivors whose lungs had been irreparably damaged by the virus, researchers reported on.
It is unclear how well these patients will do in the long term, but it appears "that lung transplantation may be an acceptable treatment for selected patients with irreversible respiratory failure due to COVID-19," they concluded.
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