WHO recommends two lifesaving treatments for Ebola virus disease.
disease . At the same time, the organization calls on the global community to increase access to these lifesaving medicines to stop Ebola from being fatal, which it too often is."The new guidance complements clinical care guidance that outlines the optimized supportive care Ebola patients should receive, from the relevant tests to administer, to managing pain, nutrition and co-infections, and other approaches that put the patient on the best path to recovery," the WHO writes.
Access to mAb114 and REGN-EB3 remains challenging, especially in resource-poor areas, where patients need them the most. Regeneron's Inmazeb, which was previously known as REGN-EB3, consists of three monoclonal antibodies of similar structure ― atoltivimab, maftivimab, and odesivimab ― which bind distinct non-overlapping epitopes on the Zaire ebolavirus glycoprotein. The three-antibody combination neutralizes the Ebola virus by blocking it from entering host cells and/or by bringing in other immune cells to target infected cells and clear them from the body.
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