Health self-management and mindfulness-based interventions conferred small, non-differing improvements to cognitive performance in older adults with subjective cognitive decline, according to a study published in Alzheimer's Research & Therapy.
Estimated change in cognitive composite scores for each trial arm. The graphs visualize the trajectories modeled using the PP linear time LMMs. The cognitive retest effect parameters were omitted from the graphed models, as these resulted in discontinuous trajectories. The time-by-arm interaction was not significant for any composite , although PACC5scores increased in both arms during the trial .
, Health Self-Management Program; LMM, linear mixed model; PP, per-protocolThe linear time LMM did not show an effect of time on attention composite scores in either the PP or ITT analyses, neither was there a significant interaction between time and trial arm. The factorial time LMM did not show a significant change for this outcome between baseline and post-intervention in PP analyses, but the ITT model showed a significant improvement over this interval.
participants at the Lyon site also showed greater attentional improvement. For the executive composite, lower baseline scores in both arms were associated with greater gains. Lower GDS-15 scores in the CMBAS arm were also associated with greater executive composite gains. See Additional fileSCD-Well was a large, multicenter RCT that randomized individuals with SCD to one of two 8-week non-pharmacological interventions.
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