A study published in Respiratory Research demonstrates an association between enhanced inhaled particle count and worse lung function due to menthol addition to e-cigarettes.
] to directly compare toxicological impact of inhaled particles form ECs + /– menthol flavoring on viability and functionality of cells and tissues present in human conducting airways. This would also enable us to take into consideration impact of non-particulate gaseous component of the EC emissions.
Our clinical study has several limitations. First, our sample size was modest. 10-year follow-up visits in the COPDGene cohort are ongoing; therefore, we hope to repeat our analysis with a larger sample size soon. Second, all participants were either current or former smokers with and without spirometry airflow obstruction.
Altogether, our findings provide new evidence of an association with altered lung function and increased number of particles inhaled due to menthol chemical addition to e-liquid. Moreover, it sets a foundation for future large-scale prospective clinical studies to demonstrate a robust relation.Here we merged biomimetic robotic engineering and analysis of a large clinical dataset to uncover evidence for a negative impact of menthol-flavored ECs on lung function and inhaled particle quantity.
]; and this in vitro finding was in line with the reported clinical outcome among VEA-containing vaping device users.The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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