A Swedish investigation of nearly 4,000 individuals over 22 years found that those with prostasin blood levels in the top quartile were 76% more likely to acquire diabetes and 43% more likely to die from cancer. According to recent research, those who have elevated levels of the protein prostasin
A Swedish investigation of nearly 4,000 individuals over 22 years found that those with prostasin blood levels in the top quartile were 76% more likely to acquire diabetes and 43% more likely to die from cancer.
The Malmö Diet and Cancer Study, a sizable population-based prospective study that has been ongoing in Malmö, a city in southern Sweden, since 1993, was the source of blood samples for the study, which is the first to examine the relationship between prostasin blood levels and cancer mortality in the general population.
Prostasin is a stimulator of epithelial sodium channels that regulate sodium balance, blood volume, and blood pressure. Moreover, prostasin has been found to suppress hyperglycemia -induced tumor growth and is associated with glucose metabolism. However, little is known about the link between prostasin, diabetes, and cancer mortality.
Researchers then examined clinical data from the same cohort until the end of 2019 to investigate associations with new cases of diabetes. Over an average 22-year follow-up, 702 participants developed diabetes. Longitudinal analyses identified a linear relationship between prostasin and incident diabetes, with participants with prostasin in the highest quartile 76% more likely to develop diabetes than those in the lowest quartile.
“Prostasin is a new potential risk marker for the development of diabetes and for cancer mortality, especially in individuals with high blood glucose levels”, says first author Dr. Xue Bao from The Affiliated Hospital of Nanjing University Medical School in Nanjing, China. “It is easily accessible, which enhances its potential to serve as a warning marker in the future.”
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